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From a histological point of view, atypical tumor glands, constituted by neoplastic epithelial cells, occur in dense desmoplastic stroma, a proper physical barrier promoting tumor growth and progression and contributing to hamper anti-tumoral response and therapeutics delivery [11,12,13,14]

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Insulin-like Growth Factor-1 (IGF-1) is a naturally occurring polypeptide hormone consisting of 70 amino acids and plays a central role in cellular growth signalling, metabolic regulation, and tissue development pathways

While both peptides can support growth and recovery, they do so via different mechanisms and with distinct outcomes

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While semaglutide-induced GERD can lead to serious long-term effects, proper management can help mitigate these risks