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1 The cross-trial caveat applies here

However, many of these drugs are poorly tolerated and are associated with significant adverse events

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Br J Cancer 76(5):678 Hu J, Liu Y, Yu Y, Zhao T, Liu S, Wang Q (1991) Diet and cancer of the colon and rectum: a casecontrol study in China

What does the post say about randomized trials comparing dual therapy against a single agent