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There were no adverse maternal or offspring effects in rats treated throughout organogenesis and lactation with 1.5 mg/kg/day phentermine and 10 mg/kg/day topiramate (approximately 2- and 3-times clinical exposures at the MRHD, respectively, based on AUC)

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Leptin is a crucial mediator that controls both immunity and feeding

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Ozempic is FDA-approved for type 2 diabetes treatment but may be prescribed off-label for weight loss at a provider's discretion and professional judgement

FDA-approved medication alternatives Five additional FDA-approved weight management medications exist beyond newer GLP-1 options