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Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter H-G et al (2018) Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

OU749 is an uncompetitive inhibitor with a K i of 17 uM [76], while GGsTop is a mechanism-based irreversible inhibitor, with an active ester of phosphonate mimicking the transition state of GSH in the GGT pocket, whose k inact /K I is 57 M 1 s 1 [77]

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Wu et al., 2019

This data suggests that GH does not augment kidney function in humans with CKD stages 34 and may be due to GH-insensitivity associated with CKD and/or generally limited renal reserve capacity in these patients ( vide supra )

& West, S