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Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes

One such adaptation she and her colleagues have been studying is an increase in the amount of the enzyme glutamine synthetase, which makes glutamine from other starting materials, namely glucose

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This effect was not sensitive to naloxone, indicating a distinct mechanism from its opioid-mediated antinociceptive effects 8

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