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Pharmacokinetic studies with canagliflozin and empagliflozin also showed an increased drug systemic exposure in patients with impaired liver function

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To provide a more thorough theoretical foundation for treating disorders associated to TMAO, larger-scale clinical trials are needed to validate TMAOs potential as a biomarker for various diseases along the gut-organ axis

The DAC technology represents a notable case study in peptide engineering aimed at solving the inherent stability limitations of short-half-life peptides like native GHRH