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Water molecules, enzymes, and potential microbial contaminants can begin to cleave the peptide bonds, slowly but surely rendering the compound useless

Nassar M, Misra A, Bloomgarden Z (2024) Impact of treatment with GLP-1RAs on suicide attempts in adults persons with type 2 diabetes: a retrospective comparative effectiveness study based on a global TriNetX health research database

Main risks are GI side effects (usually manageable by dose titration) and very rare pancreatitis or gallbladder issues (monitor for symptoms, get labs if warranted)

1H) at GLP-1R

10.1016/S1360-1385(01)01946-X 64 KornyeyevD.LoganB

Alternative NSAIDs such as naproxen may be prescribed for certain conditions, though similar gastrointestinal precautions apply