Drug effects in lean mice Single peripheral bolus administration (10 nmol kg 1 ) of GLP-1GIP and GLP-1GIPLani both induced conditioned taste avoidance (CTA) in lean wild-type mice, with GLP-1GIPLani having a slightly greater effect compared with GLP-1GIP, and without inducing CTA in glutamatergic ( Vglut2-cre ) Glp1r -knockout mice ( Vglut2 is also known as Slc17a6
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The FDA labeling reflects a theoretical concern based on rodent studies, but human evidence does not support this risk
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