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These genes have been previously implicated in critical ferroptotic processes such as lipid peroxidation, iron metabolism, and glutathione depletion (Fig

This decrease in circulating markers of the RAAS has not been consistently observed in human mechanistic studies, possibly due to differences in the study cohorts involved in these trials [68]

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Therapeutic Advances in Gastroenterology, 12 , 1756284819877788

If urate levels stay too high, urate crystals can slowly form

Textural irregularities and rough surface