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Another study revealed that gentamycin induced nephrotoxicity by over-producing of reactive oxygen species and free radicals and significantly increased serum NGAL, KIM-1 and cystatin-c whereas Irbesartan and other angiotensin II blockers reverse this effect and improve renal function through Modulation of oxidative stress and endogenous antioxidant Capacity [57]
Abbreviations, HMs, heavy metals
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doi: 10.1016/j.cgh.2018.10.021 67
Two of them (GLP-1 and GIP) are already targets for approved drugs: GLP-1 alone for semaglutide (Ozempic, Wegovy), GLP-1 and GIP together for tirzepatide (Mounjaro, Zepbound)
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