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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors Obesity, 2006, metabolic-syndrome context review PMID 16625817 Halford JC