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Relative to the control values (the number of newly formed endothelial spaces in the control group three days after implantation was 7.941.23 and seven days after implantation 14.83.12), all used substances led to significantly increased values in both intervals (the third and seventh day)

10.1016/j.placenta.2016.12.005 Placenta 71 GrayM

It also notes the reverse pattern, where someone reports minimal symptoms in the first 72 hours and then experiences cumulative gastrointestinal effects around day four or five

The funnel plot showed asymmetry between studies on both sides, suggesting the potential presence of publication bias (Figure 8)

[PMC free article: PMC3511587] [PubMed: 23143598] 385

Contact your healthcare provider if you experience: Severe or worsening pain, extensive swelling, or signs of infection (warmth, pus, fever) Discomfort that persists beyond 48 hours Any systemic symptoms such as fever or feeling generally unwell For future injections, allowing adequate warming time will likely improve your comfort and overall treatment experience