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NNMT inhibition reduces one methylation pathway, but it doesn't directly deplete systemic methyl donorsit redirects nicotinamide away from methylation toward NAD+ salvage

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Evidencia cientfica La evidencia sobre GHK-Cu se concentra en modelos preclnicos (rata, ratn, conejo) y estudios clnicos dermatolgicos con formulaciones tpicas

doi: 10.1038/s41467-017-01311-y 16 MatsunagaTSanoHTakitaKMoritaMYamanakaSIchikawaTet al

Sun W, Yang Y, Wang C, Liu M, Wang J, Qiao S, Jiang P, Sun C, Jiang S