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The move reflects a broader trend as employers weigh the benefits of obesity treatment against rising healthcare expenses, raising concerns that access to popular weight-loss drugs could become more limited despite strong patient demand

Previous studies indicate that PPARa modulates FSP1 activity through coregulator interactions, thereby contributing to ferroptosis resistance [30]

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doi: 10.3389/fmolb.2025.1724944 Received 14 October 2025 Revised 18 November 2025 Accepted 30 November 2025 Published 18 December 2025 Volume 12 - 2025 Edited by Maria Barile, University of Bari Aldo Moro, Italy Reviewed by Anna Maria Giudetti, University of Salento, Italy Maria Tolomeo, National Research Council (CNR), Italy Updates Copyright 2025 Schrder, Jalilvand, Kahl, Kaiser and Liebau

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When we eat, the digestive system breaks food down into simple sugars that enter the bloodstream