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This is why long-term or indefinite use is often needed to maintain weight loss, similar to other GLP-1 medications

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However, the majority of trials to date have found routine antioxidant supplementation during pregnancy to be ineffective in reducing the risk of preeclampsia [161, 222224]

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Many patients have taken these medications for years, often at higher doses, and new concerns are emerging about chronic gastrointestinal, neurological, pancreatic, renal, and hormonal effects