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Neither requires an oily or occluding base to work

Nutricin Hospitalaria (2007) 22(1):724

For example, in certain embodiments, a sustained and/or extended release formulation described herein comprises a combination of poloxamer 407 (pluronic F127) and carboxymethylcellulose (CMC) in a ratio of about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1.4%, about 4.5%, or about 5% of the total weight of the formulation or composition

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248251 It also suppressed neuropathy, depression, and anxiety in T2D-associated peripheral neuropathy patients

The central autonomic network: functional organization, dysfunction, and perspective