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While TNF- was also reported as modified in blood, results were inconsistent, reporting increases [13, 29], decreases [12, 30] or no change [32, 39, 44, 60, 67], both within small or large cohorts

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Pain from the sphincterotomy is usually mild and is often less than the pain of the fissure itself

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Longer-term ALC administration was not feasible due to resource constraints