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Two strategies were employed to achieve this, the first centered around synthetically engineering GLP-1R agonism into a glucagon core sequence, while the other focused on protracting the half-life of oxyntomodulin via a DPP-IV-resistant dSer2 substitution and cholesterol linkage (DualAG) [140], [43]

Saporita AJ, Zhang Q, Navai N, Dincer Z, Hahn J, Cai X, et al

Diabetes mellitus induces Alzheimers disease pathology: Histopathological evidence from animal models

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Since GLP-1 medications slow stomach emptying and can reduce appetite, thirst cues may be blunted, making it easier to unintentionally underdrink, says McGowan