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The biological rationale is interesting but unproven

Protection Against Toxins and NSAIDs: Prevents lesions and gastrointestinal injury caused by medications, toxins, or stress

Complications of Polypharmacy Polypharmacy can lead to several problems, including adverse drug events (ADEs), inappropriate medication uses in the elderly, drug interactions, higher treatment costs, more hospitalizations, and increased mortality

doi: 10.2147/jir.S219586 59 WieseMDManning-BennettATAbuhelwaAY

(2006) A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels

A normal response to the stimulus was first determined in the unoperated left hind limb and was defined as an immediate withdrawal of the limb with or without a vocalization