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A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex

In subunit 1, the N-terminal domain I helices are shown in dark blue, and -strands are shown in red, and the C-terminal domain II helices are shown in light blue

Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and oxidative stress in an animal model of Gulf War illness

Our experimental results indicate that PGC-1 can bind to these mRNAs, but their enrichment was significantly reduced following si-PGC-1 LNP treatment (Fig

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