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Obesity also negatively affects the efficacy of biologic treatment in patients with psoriasis (205)

Current approaches are largely restricted to experimental settings, while available inhibitors, such as non-specific antioxidants or iron chelators, exhibit limited specificity and raise safety concerns related to off-target effects and disruption of systemic iron homeostasis

Butler JM, Chan SC, Stevens S, & Hanifin JM (1983) Increased leukocyte histamine release with elevated cyclic AMP-phosphodiesterase activity in atopic dermatitis

It has niacinamide, kojic acid, and tranexamic acid to help lighten discolorations, says Purvisha Patel, MD, a board-certified dermatologist based in Memphis, Tennessee

10.3390/jpm14101054 88 VermaA.PatelA

Some formulations include cagrilintide peptide, offering a more comprehensive metabolic intervention for those who qualify under medical supervision