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The receptor pharmacology is classical: GLP-1R binding on pancreatic beta cells and extra-pancreatic tissues including CNS, stomach, and cardiovascular tissues, with Gs-adenylyl cyclase-PKA downstream signaling

This additional mechanism may translate to better blood sugar control and more sustainable weight loss, especially for people whose bodies respond less robustly to single-receptor GLP-1 therapy alone

& Thonar, E

Minor bruising can occur