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Species interaction at the cellular level, dispersion or intercellular lipids extraction, increased fluidity of stratum corneum lipid bilayers, higher drug thermodynamic activity, and greater SC hydration are all mechanisms that support drug administration using chemical enhancers [283]

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Tirzepatide: What It Is and How It Works Tirzepatide is the active ingredient in Mounjaro (approved for type 2 diabetes) and Zepbound (approved for chronic weight management)