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The medication provides neurochemical support for changes that lifestyle factors must sustain

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Factors such as body weight, metabolic rate, insulin sensitivity, gut microbiome composition, and genetic differences in receptor expression can all influence how effectively the medication suppresses appetite in any given person

Resistance training becomes particularly important to preserve muscle mass during weight loss

Why Starting at 2 mg Matters The Phase 2 trial included a direct comparison: one 4 mg group started at 2 mg and escalated, while another started directly at 4 mg

Effect of GLP-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis