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The main mechanism of drug induced liver injury is due to the toxicity of the drug itself and the immune reaction, most of the drugs are transformed by hepatocytes, and normal medication will not cause liver injury, but after overdose, a large number of drugs are transformed into water-soluble metabolites by hepatocytes, and the generation of these substances will greatly consume the glutathione in the hepatocytes, resulting in hepatocellular necrosis, and the exogenous glutathione can reduce the toxicity of the drug and the immune reaction, which will cause the liver cell necrosis

Any medications that are processed through your liver, as glutathione could potentially affect this process

NAC generally requires 1-2 weeks of consistent use to build sufficient glutathione levels, but provides more sustained long-term benefits

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Ketosis is a metabolic process that occurs when your body doesnt have enough glycogen (stored glucose from carbs) to use as energy due to your reduced carbohydrate intake

Nielsen MJ, Rasmussen MR, Andersen CB, Nexo E, Moestrup SK