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KPV's smaller molecule size and more targeted mechanism may contribute to its cleaner anecdotal side effect profile, though long-term human data do not exist for either compound

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Exp Biol Med 241:689696 Zhang D, Xu C, Manwani D, Frenette PS (2016) Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

10.1007/s00204-017-2050-6 69 HuangJ.-Y.YehP.-T.HouY.-C