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Maintenance: Repeat protocol 1-3 times a year

Fitzpatrick MF, Engleman HM, Boellert F, McHardy R, Shapiro CM, Deary IJ, Douglas NJ (1992) Effect of therapeutic theophylline levels on the sleep quality and daytime cognitive performance of normal subjects

When activated by SLU-PP-332, ERR increases mitochondrial biogenesis, enhances fat oxidation, and improves metabolic efficiencysimilar to endurance exercise training

Isolated vomiting is less common and usually self-limiting within days

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From the preclinical data for putative benefits there were also important side effects noted