I think the reason we are seeing these increased reports of side effects (150 cases of self harm or suicidal ideation in the EU, which is a small number) is simply because more people are taking them and because people are mistaking the secondary effects of weight loss with the side effects of the drug
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Ceriello A (2000) Oxidative stress and glycemic regulation
Other health factors can add to the challenge: Insulin resistance or prediabetes makes it easier to store fat, particularly around the abdomen Busy schedules that limit sleep and increase stress, both of which influence hunger hormones Joint discomfort or fatigue that makes high-intensity exercise unrealistic In these situations, medical support can make a meaningful difference
Slower titration for anxiety-prone individuals If you have a history of anxiety or are experiencing anxiety symptoms during titration, discuss a slower schedule with your prescriber
3 Due to high demand, brand-name semaglutide medications like Ozempic and Wegovy are often in short supply