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Additional Notes on the Literature While digging into the peer reviewed articles, we found a few observations and concerns we would like to point out

The mechanism matters because it often predicts the balance between blood-sugar benefit and weight loss effect

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JAMA Surgery study of 1,046 patients identified independent risk factors for food retention with GLP-1 RA use (odds ratio 9.19, 95% confidence interval 2.7330.8), with tirzepatide demonstrating the strongest association amongst available agents [33]