Amylin receptors are heterodimers of the calcitonin receptor (CTR) with receptor activity-modifying proteins, giving AMY1, AMY2 and AMY3, and cagrilintide activates these alongside CTR itself, which is why the literature classifies it as a dual amylin and calcitonin receptor agonist rather than a selective amylin analogue
Retatrutide also demonstrated positive effects on insulin sensitivity and glycemic control, with nearly three-quarters of prediabetic participants returning to normal blood sugar levels after 48 weeks of treatment [R]
1,2 When traveling with their Ozempic pen, advise patients to: Transport in Carry-on: Always keep Ozempic pen in carry-on luggage, not checked baggage, to mitigate extreme temperature fluctuations
Patients also taking insulin or sulfonylureas with tirzepatide should be particularly vigilant about hypoglycaemia risk
Its also important to be cautious about compounded versions of GLP-1s
Severe diabetic retinopathy or proliferative retinopathy