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The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose

This creates shame and frustration, which deepens the depression further

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Too much strain will result in muscle breakdown

As a result, over 75% of OC patients are diagnosed at an advanced stage, which is related with poor therapeutic effect and high mortality (53)

Non-drowsy antihistamines like cetirizine (Zyrtec) and loratadine (Claritr) are generally safe with semaglutide injections