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Ex-4 or vehicle was perfused through the microdialysis probe concurrently with cocaine (Supplementary Figure 2B)

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Semaglutide treatment improves coverage of astrocytes in the cortical and hippocampal capillaries of animals with metabolic syndrome Immunohistochemical analysis allowed the evaluation of vessel coverage by astrocytes on the cerebral microcirculation, which is an essential feature of the neurovascular unit and blood brain barrier (BBB) integrity

Its primary role is to stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it only releases insulin when blood sugar levels are high