Berendsen, C
Beyond its antioxidant functions, glutathione is involved in various important biochemical processes
Mechanistically, augmented ischemia-reperfusion injury in the absence of GPx-1 may be caused by increased NFB activation, as pyrrolidine dithiocarbamate (PDTC), an NFB inhibitor, partially protects against neurotoxicity in this model (82)
Laboratories sourcing glutathione in the UK generally use it as a defined reductant and as a substrate for GST and GPx assays in oxidative stress, xenobiotic conjugation and ferroptosis models
Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage
She always has her patients health and best interest in mind when she recommends a treatment plan
