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Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimers disease model

Latzman JM, Kong L, Liu C, Samadani U

Metformin and B12 Depletion in Diabetic Patients Metformin is a common drug for type 2 diabetes

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The pattern is consistent: strong mechanistic plausibility from preclinical data and adjacent human safety, no direct human efficacy or long-term safety data on IGF-1 LR3 itself