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The initial step in designing a PCSK9/GLP-1 dual molecule was to fuse a DPP-4-resistant GLP-1 analogue peptide with either GGSA or [G 4 S] 3 A linkers to the heavy or light chain variable domains of a panel of anti-PCSK9 antibodies

Gradual Titration: The Cornerstone of Safe Dosing Starting semaglutide therapy typically involves a gradual increase in dosage over several weeks, known as titration

GLP-1 drugs are indicated for patients with obesity, i.e

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Puig et al., 2015