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Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, distinguishing it from currently approved weight management agents

Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease

Conclusions Treatment with semaglutide, compared to placebo, is associated with significant lower incidence of all-cause and CV mortality, as well major CV and kidney events across the continuum of cardio-kidney-metabolic syndrome

Loss of muscle mass may occur on GLP-1s