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GABA in the glia can act as a metabolic substrate and be finally re-converted to glutamine, transferred to neurons, and converted to glutamate, which re-enters the GABA shunt

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10.1124/jpet.102.053124 J

Based on the above Chinese and international research findings, it can be concluded that metformin inhibits the proliferation and diffusion of glioma cells by stimulating the AMPK/mTOR signaling pathway, and this mechanism has been verified in experiments and clinical trials