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Secondary objectives were change from baseline to week 3 for tirzepatide versus placebo in fasting and postprandial appetite VAS ratings, FCI, FCQ-S, Eating Inventory, PFS questionnaire ratings and BOLD activation to photos of Food HiPal (Food HiF/HiS and Food HiF/HiC ) relative to non-food during the fasting state in the prespecified principal reward ROIs

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By helping regulate appetite and feelings of fullness, the medication may ease some of the increased hunger and cravings that can accompany the hormonal changes experienced during perimenopause and menopause

Management outcomes highlight the need for individualized and multidisciplinary approaches to improve symptom control and quality of life

Genetic research is identifying polymorphisms that predict superior response to the combination therapy