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Unfortunately, there is a gap in the study of the interactions between mitochondrial quality control and metal ions, the effect of metal ions on mitochondrial function has rarely been studied, and most of the relevant studies have focus only on mitochondrial dynamics and oxidative stress

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Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase 1 (MMP-1) in human cells

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Therefore, discovering a small molecule GLP-1RA that could be orally administered is a current but extremely challenging research hotspot

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