Finally, to expand on the opportunity for NMDA receptor antagonism as a complementary pharmacological partner to GLP-1 receptor agonism, we pretreated DIO mice with semaglutide for 14 days and subsequently randomized the mice to stay on semaglutide in combination with either GLP-1MK-801 or the GLP-1 monotherapy (Fig
Notably, although semaglutide resulted in a slightly less pronounced weight loss, it elicited a significantly greater aversive response compared with GLP-1MK-801 (Fig
19 (Suppl
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130 For example, a popular dual agonist, tirzepatide (brand name Mounjaro), activates both GLP-1 and GIPR