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In the Phase 3 TRIUMPH-1 trial, the highest-dose retatrutide group averaged 28.3% weight loss at 80 weeks

INDIVIDUAL RESULTS VARY Results from tirzepatide treatment vary significantly between individuals

And by 2024, the figure reached $300 million

Side effects looked very similar to other GLP-1 medications, especially during dose increases: Nausea Diarrhoea Constipation Vomiting These were more common at higher doses

In 2023, the FDA and European Medicines Agency (EMA) began investigating a possible relationship after receiving reports of suicidal thoughts while patients were taking the drugs

Researchers believe the compounds effectiveness comes from its triple-receptor activity: GLP-1 Activation GLP-1 signaling is associated with appetite regulation and improved glucose control