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A 2019 study in Dermatologic Surgery comparing localized versus systemic botulinum toxin for hyperhidrosis found that systemic administration produced more uniform results across larger treatment areas

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Using NMR metabolomics and flow cytometry to detect the Treg proportion, it was found that butyrate, as a histone deacetylase (HDAC) inhibitor, can enhance histone H3 acetylation of the Foxp3 gene and directly promote the differentiation of colonic Tregs

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That literature is useful for topical context