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Hydroquinone is used in short cycles rather than continuously, and daily sunscreen is essential or pigment returns

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[DOI] [PubMed] [Google Scholar] 9.Wadden T

E2 might be involved in modulating BAFF levels, resulting in a higher incidence of AITD in women (132134)

Luckily, it appears to be a very safe medication for the majority of patients, but many dogs with only mild enlargement never experience clinical signs of congestive heart failure in the first place, so treating them long-term with pimobendan does not change their clinical outcome