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If significant weight loss is not achieved after 16 weeks, your Centra Internal Medicine provider will reassess your treatment plan and discuss next steps with you

Choose phentermine if you: Need a lower-cost appetite tool with fast impact Prefer a tablet over injections Want a short-term reset with coaching and accountability Consider GLP-1s if you: Aim for larger total body-weight loss and can tolerate injections or oral GLP-1 dosing Have metabolic comorbidities where GLP-1 therapy provides additional benefits Have coverage/savings that reduce out-of-pocket cost Are willing to make a permanent financial commitment, as all studies show a very high rate of weight regain when stopping GLP-1s

GLP-1 is a gut neuropeptide, and GLP-1 analogues are successfully used in patients with and without type 2 diabetes mellitus to aide weight loss and improve long-term outcomes

And it minimizes the risk of severe nausea or vomiting that could lead to early discontinuation

1 mL Trizol reagent was added to lyse the tissues and extract total RNA

Metabolic adaptation affects everyone who loses significant weight, regardless of method