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The risk of gastrointestinal bleeding increases significantly with age, especially in patients older than 75 years

A randomised controlled trial published in Diabetes Care reported that co-administration of probiotics with GLP-1 therapy resulted in significant improvements in fasting glucose levels and cholesterol profiles, suggesting an additive effect on metabolic parameters

Most therapeutic protocols use 12-24 week cycles based on research protocols and individual goals

Which nutrients are most at risk on GLP-1 therapy

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Tier 2 (clinician contact within 48 hours): Vomiting more than twice daily for two consecutive days, constipation lasting more than five days without relief, or weight loss stalling with severe GI symptoms at a low dose