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In 2024, 106 cases were reported, and only a few reports with this side effect were submitted prior to 2024

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The debenzylating agent in step-c) is selected from Pd/C, Raney-Ni, Pd(OH)2/C, palladium acetate, platinum oxide, Rhodium and the like

demonstrated that PBAcrosslinked nanoparticles could selectively release doxorubicin (Dox) in the acidic microenvironment of tumors, thereby enhancing therapeutic effectiveness and alleviating cardiotoxicity [450]

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