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Intestinal dysbiosis is characterized by a reduction in the flora producing anti-inflammatory metabolites (such as short-chain fatty acids and secondary bile acids) and their encoding genes, along with an enrichment of flora producing the pro-inflammatory metabolite trimethylamine, resulting in metabolic imbalance

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Regarding the active site of GSH peroxidases, the selenocysteine localized in position 46 (Sec 46 ) showed to be essential for the human GPX4 [30]

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Sheila Kilbane, Deborah Allen, RPh, Dr