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Calcitonin has a strong hypocalcaemic effect via inhibition of osteoclasts ( Figure 1 ) (79) and promotion of renal excretion of calcium, presumably by inhibiting tubular reabsorption of calcium (79)

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The authors hypothesised that xCT inhibition might be further potentiated by limiting glutamate or glutamine availability, and show that xCT is a compelling therapeutic target for triple-negative tumours