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GLP-1R agonists may exert antidepressant effects by modulating inflammatory processes in the brain Chronic inflammatory processes in the brain associated with excessive activation of microglia and increased production of pro-inflammatory cytokines are one of the key factors leading to the development of depressive symptoms, as patients suffering from this mental illness are very often characterized by elevated levels of tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 beta (IL-1), C-reactive protein (CRP), and interferon-gamma (IFN-) in the cerebrospinal fluid and the blood [59,60,61]
Between 6% and 12% of Americans use GLP-1 drugs, a share that will rise sharply as Medicare coverage substantially expands and prices in the cash-pay market drop to ~$250 per month over the next few years
Last week, shares of the Danish pharmaceuticals stock tumbled as much as 27% on news that compounded pharmaceuticals firm Hims & Hers Health (NYSE: HIMS) would begin selling its own version of Novo's new Wegovy GLP-1 weight loss pill for just $49 per month
Standard weekly dosing follows the protocol used in clinical research, where participants started at low doses and increased every four weeks
However, since the FDC has not been approved in major markets like the USA, Europe, and India, the evidence from these studies is beyond the scope of this review
