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Figure 3 Moreover, increased systematic translocation of intestinal metabolites, bacterial particulates, or even microbiota through the damaged intestinal tract (the leaky gut) heightens systemic inflammatory reactions such as Th17/Treg disorder, interleukin-6, IL-1, and tumor necrosis factors alpha that are being implicated in the etiology of depression

Finally, we found that the appetite suppressant effect of tesofensine is not because of the induction of taste aversion

*Clinical study

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PMID: 25388162